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. 2018 Jun 19;315(4):E446–E453. doi: 10.1152/ajpendo.00130.2018

Fig. 2.

Fig. 2.

Tadalafil treatment increases the tissue cGMP level in young rats. A: rats were weighed weekly during the 3-wk tadalafil treatment period. n = 10 rats/group. B: ELISA analysis of cGMP amount in brain tissue of rats treated with vehicle, 2.5 mg/kg or 10 mg/kg tadalafil daily for 3 wk. n = 5 rats/group. C: ELISA analysis of cGMP amount in brain tissue of rats at 0, 3, 6, and 24 h after receiving 1 dose of 10 mg/kg tadalafil. n = 3 rats/time point. *P < 0.05, 2.5 mg/kg tadalafil vs. vehicle; **P < 0.01, 2.5 mg/kg tadalafil vs. vehicle; aP < 0.05, 10 mg/kg tadalafil vs. vehicle; bP < 0.01, 10 mg/kg tadalafil vs. vehicle; #P < 0.05 vs. 0 h by two-way (A) or one-way ANOVA (B and C) with Bonferroni’s post hoc test for multiple comparisons. cGMP, cyclic GMP; veh, vehicle.