Fig. 6.
Metabolic phenotype of aged AMiSKO mice. Characterization of aged male AMiSKO and flox/flox mice. A: body composition in 20- to 23-mo-old mice (n = 5–7 per group). Blood glucose concentrations during the IPGTTs (B) and ITTs (C) were determined in 18- to 21-mo-old mice (n = 8–9 per group). AUC for glucose is shown next to each curve. D: plasma lipid profile was determined in 18- to 21-mo-old mice (n = 7–9 per group). E: whole body V̇o2, RER, and EE were determined in 21- to 23-mo-old mice (n = 4 per group). There was a significant time effect (P < 0.05) but no group × time interaction in IPGTTs and ITTs data (ANOVA). Values are means ± SE.