Table 3.

Upstream regulators identified from proteins that were increased or decreased in mice fed the HFD compared with mice fed the LFD

Upstream regulators of proteins	P Value
Increased with HFD
Pirinixic acid	1.09 × 10–23
Bezafibrate	1.71 × 10–22
PPARα	5.33 × 10–21
PPARδ	5.16 × 10–20
Fenofibrate	1.41 × 10–17
Decreased with HFD
EBF1	2.42 × 10–4
Interleukin 15	4.96 × 10–4
TRPC4AP	5.00 × 10–4
Huntingtin	3.27 × 10–3
PGC-1α	3.88 × 10–3

HFD, high-fat diet; LFD, low-fat diet; PPAR, peroxisome proliferator-activated receptor; EBF1, early B cell factor 1; TRPC4AP, transient receptor potential cation channel subfamily C member 4-associated protein; PGC1α, peroxisome proliferator-activated receptor-γ coactivator 1α.