Table 4.
GSEA of proteins that decreased in skeletal muscle mitochondrial fractions from mice fed the HFD compared with mice fed the LFD for 12 wk
| GSEA Identification | Pathway | No. of Genes | FDR |
|---|---|---|---|
| R-MMU-2151209 | Activation of PGC-1α by phosphorylation | 3 | 4.65e-02 |
| R-MMU-200425 | Import of palmitoyl-CoA into mitochondrial matrix | 3 | 4.65e-02 |
| R-MMU-199991 | Membrane trafficking | 12 | 4.65e-02 |
| R-MMU-109703 | Protein kinase B-mediated events | 4 | 4.65e-02 |
| R-MMU-165159 | mTOR signaling | 4 | 4.65e-02 |
| R-MMU-5653656 | Vesicle-mediated transport | 12 | 4.97e-02 |
| R-MMU-5628897 | Tumor protein 53 regulates metabolic genes | 4 | 4.97e-02 |
| R-MMU-163685 | Integration of energy metabolism | 5 | 8.87e-02 |
| R-MMU-1592230 | Mitochondrial biogenesis | 3 | 8.87e-02 |
| R-MMU-163680 | AMPK inhibits chREBP transcriptional activation activity | 2 | 9.78e-02 |
GSEA, gene set enrichment analysis; HFD, high-fat diet; LFD, low-fat diet; FDR, false discovery rate; PGC1α, peroxisome proliferator-activated receptor-γ coactivator 1α; mTOR, mechanistic target of rapamycin; AMPK, AMP-activated protein kinase; chREBP, carbohydrate-responsive element-binding protein.