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Acute FGF23 administration increases isolated heart contractility. A: representative force tracings of isolated mouse heart muscle paced at 1 Hz at baseline (before vehicle or FGF23 treatment) and after 30 min of exposure to vehicle or 9 ng/ml FGF23. B: summary data of whole heart contractile force output after 30 min of vehicle or 9 ng/ml FGF23 exposure. Data are expressed as fold change of contractile force relative to baseline; n = 4–6 hearts/group. *P < 0.05, 2-tailed t-test.
