Fig. 3.

Attenuated cardiac hypertrophy in response to high-dose (1,000 ng·kg⁻¹·min⁻¹) angiotensin II (ANG II)-induced hypertension in female SMKO mice. Heart weight-to-body weight ratio in control and SMKO female mice was determined before and after 4 wk of ANG II infusion. Baseline heart weight-to-body weight ratio did not differ between control (n = 5) and SMKO (n = 4) mice before infusion. There was significant cardiac hypertrophy in ANG II-treated control (n = 14) and SMKO (n = 16) mice compared with their respective baseline groups. Values are means ± SE. Data were analyzed by 2-way ANOVA with Sidak’s post hoc test for multiple comparisons: **P = 0.004 for SMKO + ANG II (6.7 ± 0.2 mg/g) vs. baseline (5.0 ± 0.4 mg/g); ***P < 0.0001 for control + ANG II (7.5 ± 0.3 mg/g) vs. baseline (4.9 ± 0.1 mg/g). After ANG II infusion, heart weight-to-body weight ratio was significantly lower in SMKO than control mice (6.7 ± 0.2 vs. 7.5 ± 0.3 mg/g). *P = 0.04.