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. 2018 Jun 13;315(4):F997–F1005. doi: 10.1152/ajprenal.00639.2017

Fig. 5.

Fig. 5.

Urinary norepinephrine levels in female mice lacking type 1A angiotensin receptors in vascular smooth muscle cells. A: at baseline, urinary norepinephrine excretion was increased in SMKO (n = 8) compared with control (n = 8) mice. Norepinephrine excretion was increased in control and SMKO mice after 5 days of angiotensin II (ANG II) infusion compared with baseline. Urinary norepinephrine excretion was significantly greater in SMKO mice after 5 days of ANG II infusion. ANOVA table for genotype: F(1,14) = 12.23, P = 0.004; Sidak’s post hoc test: P = not significant for baseline, ***P = 0.0008 for day 5 of ANG II. B: to account for differences in urine volume at day 5, norepinephrine is expressed as ratio of urinary norepinephrine to creatinine in SMKO (n = 8) and control (n = 8) female mice at baseline and day 5 of ANG II infusion. ANOVA table for time: F(1, 14) = 9.9, P = 0.007; Sidak’s post hoc test: P = not significant for baseline, *P = 0.02 for day 5 of ANG II. C: 24-h urine excretion was increased in SMKO (n = 8) compared with control (n = 8) mice at day 5 of ANG II infusion. ANOVA table for genotype: F(1,14) = 8.21, P = 0.01; Sidak’s post hoc test: P = not significant for baseline, **P = 0.006 for day 5 ANG II. D: 24-h food consumption was increased in SMKO (n = 8) compared with control (n = 8) mice at day 5 of ANG II infusion. ANOVA table for genotype: F(1,14) = 6.03, P = 0.03; Sidak’s post hoc test: P = not significant for baseline, ***P = 0.002 for day 5 of ANG II. Values are means ± SE. Data were analyzed by 2-way repeated-measures ANOVA with Sidak’s post hoc test for multiple comparisons.