Fig. 9.
Ferroportin (FPN) knockout (KO) by Nestin-Cre protected from ischemic acute kidney injury (AKI). Representative hematoxylin and eosin staining (A) and tubular injury score (B) showed less severe damage in ischemic kidneys of floxed FPN (FPNf/f)/Nestin-Cre vs. WT mice (ischemia, 20 min; reperfusion, 48 h). Scale bar, 100 µm. Both serum creatinine (sCr; C) and blood urea nitrogen (BUN; D) were lower in FPNf/f/Nestin-Cre than in WT mice with ischemic AKI. Data are presented as means ± SE (3 mo; n = 8, male) and were analyzed using Student’s t-test.