Table 6.
List of assigned resonances that undergo a significant change in intensity at 72 h posthypoxia
| Metabolites | ppm | 72-h P value | Fold Change | VIP | AUC |
|---|---|---|---|---|---|
| 2-Oxoisocaproate | 0.907 | 0.665200686 | 1.145 | 1.563 | 0.511 |
| Trimethylamine N-oxide | 3.269 | 0.683757724 | 1.154 | 1.519 | 0.511 |
| Benzoate | 7.879 | 0.027736072 | −3.057 | 1.414 | 0.830 |
| Benzoate | 7.487 | 0.025178825 | −2.701 | 1.411 | 0.807 |
| Benzoate | 7.554 | 0.495765072 | −1.250 | 1.041 | 0.545 |
| Betaine | 3.243 | 0.634824836 | 1.189 | 1.379 | 0.523 |
| d-Fructose | 3.905 | 0.50873211 | 1.276 | 1.324 | 0.534 |
| d-Fructose | 4.016 | 0.451011233 | 1.339 | 1.312 | 0.591 |
| d-Fructose | 3.733 | 0.624044729 | 1.185 | 1.262 | 0.523 |
| d-Fructose | 4.641 | 0.303251846 | 1.476 | 1.122 | 0.568 |
| Trimethylamine | 2.878 | 0.127594079 | −1.979 | 1.315 | 0.727 |
| Alanine | 1.482 | 0.006418194 | −2.423 | 1.262 | 0.864 |
| cis-Aconitate | 5.693 | 0.153824949 | −1.477 | 1.238 | 0.682 |
| cis-Aconitate | 3.114 | 0.319643873 | −1.407 | 0.824 | 0.670 |
| 1-Methylnicotinamide | 8.205 | 0.006816209 | −2.142 | 1.225 | 0.864 |
| 1-Methylnicotinamide | 8.941 | 0.410475738 | −1.307 | 1.206 | 0.727 |
| 1-Methylnicotinamide | 9.280 | 0.673375581 | −1.149 | 0.759 | 0.511 |
| 1-Methylnicotinamide | 8.898 | 0.424973825 | −1.359 | 0.669 | 0.602 |
| Sumiki's acid | 4.609 | 0.13751331 | 2.022 | 1.203 | 0.659 |
| Sumiki's acid | 6.485 | 0.829412829 | 1.053 | 1.102 | 0.500 |
| Indoxyl sulfate | 7.358 | 0.86197806 | 1.061 | 1.190 | 0.545 |
| Indoxyl sulfate | 7.707 | 0.353053752 | −1.280 | 0.804 | 0.670 |
| Indoxyl sulfate | 7.213 | 0.043564136 | −1.781 | 0.799 | 0.773 |
| Indoxyl sulfate | 7.271 | 0.077814986 | −1.609 | 0.785 | 0.761 |
| Hippurate | 7.824 | 0.857729839 | −1.076 | 1.185 | 0.557 |
| Hippurate | 7.680 | 0.879563072 | −1.054 | 0.895 | 0.545 |
| Hippurate | 7.781 | 0.15570119 | −1.479 | 0.850 | 0.727 |
| Lactate | 1.332 | 0.012295895 | −3.296 | 1.181 | 0.852 |
| Acetate | 1.922 | 0.02028213 | −2.594 | 1.177 | 0.807 |
| myo-Inositol | 3.300 | 0.857086379 | −1.069 | 1.149 | 0.568 |
| myo-Inositol | 3.546 | 0.198287503 | −1.391 | 0.672 | 0.705 |
| Isethionic acid | 3.963 | 0.793373292 | −1.104 | 1.142 | 0.511 |
| Isethionic acid | 3.161 | 0.195158898 | −1.512 | 0.782 | 0.716 |
| trans-Aconitate | 3.487 | 0.832702286 | −1.070 | 1.081 | 0.614 |
| trans-Aconitate | 6.590 | 0.329370704 | −1.483 | 0.623 | 0.602 |
| Guanidineacetic acid | 3.789 | 0.940239682 | −1.023 | 1.038 | 0.545 |
| 3-Hydroxyisobutyric | 1.126 | 0.854154735 | −1.081 | 1.013 | 0.659 |
| Creatinine | 3.048 | 0.02215601 | −1.646 | 1.010 | 0.795 |
| Creatinine | 4.059 | 0.073006945 | −1.515 | 0.821 | 0.750 |
| Dimethylamine | 2.721 | 0.040216322 | −1.663 | 0.917 | 0.750 |
| Putrescine | 1.753 | 0.177510646 | −1.407 | 0.910 | 0.739 |
| Ethanol | 1.209 | 0.442675863 | −1.237 | 0.893 | 0.648 |
| Ethanol | 3.653 | 0.276054143 | −1.328 | 0.813 | 0.636 |
| Acetylphosphate | 2.046 | 0.159000279 | −1.477 | 0.813 | 0.705 |
| Succinate | 2.405 | 0.063856472 | −1.975 | 0.800 | 0.705 |
| Valine | 1.016 | 0.260379445 | −1.442 | 0.768 | 0.705 |
| Valine | 0.993 | 0.137121106 | −1.733 | 0.747 | 0.818 |
| threo-Isocitric acid | 2.451 | 0.065367075 | −1.819 | 0.742 | 0.750 |
| threo-Isocitric acid | 2.504 | 0.150216366 | −1.565 | 0.717 | 0.739 |
| Trigonelline | 4.477 | 0.588856426 | −1.135 | 0.723 | 0.591 |
| Trigonelline | 8.837 | 0.394839552 | −1.416 | 0.693 | 0.614 |
| Trigonelline | 9.124 | 0.3552089 | −1.457 | 0.665 | 0.602 |
| Dimethylbiguanide | 3.005 | 0.232931607 | −1.578 | 0.705 | 0.682 |
| Citrate | 2.673 | 0.124007035 | −2.687 | 0.668 | 0.795 |
| Citrate | 2.539 | 0.179350784 | −2.532 | 0.621 | 0.773 |
AUC, area under the curve; ppm, parts/million; VIP, variable importance in projection.