Table 8.
List of assigned resonances that undergo a significant change in intensity at 168 h posthypoxia
| Metabolites | ppm | 168-h P Value | Fold Change | VIP | AUC |
|---|---|---|---|---|---|
| Trimethylamine* | 2.878 | 0.005237464 | 2.990 | 1.623 | 0.826 |
| Alanine | 1.482 | 0.004733452 | −1.907 | 1.496 | 0.876 |
| Hippurate | 7.824 | 0.383418902 | 1.919 | 1.387 | 0.669 |
| Hippurate | 7.781 | 0.924060435 | −1.021 | 1.079 | 0.529 |
| Hippurate | 7.680 | 0.986256144 | −1.008 | 1.041 | 0.562 |
| Creatinine | 3.048 | 0.010147793 | −1.393 | 1.226 | 0.777 |
| Creatinine | 4.059 | 0.055712789 | −1.393 | 1.008 | 0.752 |
| Trigonelline | 9.124 | 0.276302446 | 1.623 | 1.224 | 0.612 |
| Trigonelline | 8.837 | 0.267466063 | 1.553 | 1.215 | 0.645 |
| d-Fructose* | 4.641 | 0.026678948 | −2.125 | 1.195 | 0.851 |
| d-Fructose | 3.605 | 0.802115334 | −1.073 | 1.032 | 0.537 |
| d-Fructose | 3.733 | 0.51166055 | −1.305 | 0.910 | 0.628 |
| d-Fructose | 3.699 | 0.170264542 | −1.500 | 0.893 | 0.711 |
| d-Fructose | 3.905 | 0.448886254 | −1.386 | 0.890 | 0.645 |
| d-Fructose | 4.016 | 0.498782251 | −1.404 | 0.867 | 0.653 |
| 3-Hydroxyisobutyric | 1.126 | 0.736324646 | 1.153 | 1.178 | 0.636 |
| 2-Oxoisocaproate | 0.907 | 0.870378952 | 1.047 | 1.171 | 0.512 |
| Isethionic acid | 3.161 | 0.020442884 | −1.761 | 1.127 | 0.818 |
| myo-Inositol | 3.300 | 0.960711134 | 1.016 | 1.108 | 0.529 |
| myo-Inositol | 3.546 | 0.09395062 | −1.485 | 0.957 | 0.694 |
| cis-Aconitate | 3.114 | 0.946809292 | 1.020 | 1.107 | 0.579 |
| cis-Aconitate | 5.693 | 0.689561323 | −1.092 | 0.888 | 0.579 |
| Dimethylbiguanide | 3.005 | 0.951493279 | 1.015 | 1.063 | 0.529 |
| 1-Methylnicotinamide | 8.941 | 0.043055172 | 1.997 | 1.029 | 0.702 |
| 1-Methylnicotinamide | 9.280 | 0.735239408 | 1.071 | 0.749 | 0.537 |
| 1-Methylnicotinamide | 8.898 | 0.754563498 | 1.068 | 0.447 | 0.562 |
| Betaine | 3.243 | 0.909095455 | −1.036 | 1.024 | 0.711 |
| Succinate | 2.405 | 0.879224753 | 1.066 | 0.954 | 0.653 |
| Acetylphosphate | 2.046 | 0.188565114 | −1.270 | 0.928 | 0.727 |
| Lactate | 1.332 | 0.085813792 | −2.587 | 0.922 | 0.686 |
| Lactate | 4.122 | 0.210007164 | −1.795 | 0.813 | 0.669 |
| Sumiki's acid | 6.970 | 0.588884304 | −1.103 | 0.911 | 0.694 |
| Sumiki's acid | 4.609 | 0.098209184 | −2.110 | 0.895 | 0.777 |
| Sumiki's acid | 6.485 | 0.679355218 | −1.110 | 0.821 | 0.752 |
| Valine | 0.993 | 0.071519276 | −1.266 | 0.907 | 0.736 |
| Valine | 1.016 | 0.186895842 | −1.199 | 0.861 | 0.686 |
| Ethanol | 3.653 | 0.283334914 | −1.348 | 0.906 | 0.653 |
| Ethanol | 1.209 | 0.174038668 | −1.307 | 0.880 | 0.736 |
| Guanidineacetic acid | 3.789 | 0.284697335 | −1.443 | 0.885 | 0.694 |
| Dimethylamine | 2.721 | 0.1009823 | −1.265 | 0.872 | 0.686 |
| Indoxyl sulfate | 7.271 | 0.207652298 | −1.409 | 0.823 | 0.653 |
| Indoxyl sulfate | 7.707 | 0.34065528 | −1.280 | 0.808 | 0.645 |
| Indoxyl sulfate | 7.358 | 0.265068631 | −1.607 | 0.779 | 0.653 |
| Citrate | 2.539 | 0.161666014 | −1.579 | 0.762 | 0.711 |
| Citrate | 2.673 | 0.418746589 | −1.266 | 0.663 | 0.645 |
| Putrescine | 1.753 | 0.48871098 | −1.114 | 0.721 | 0.628 |
| Benzoate | 7.879 | 0.165257291 | −1.494 | 0.719 | 0.661 |
| Benzoate | 7.487 | 0.16570031 | −1.478 | 0.710 | 0.653 |
| Acetate | 1.922 | 0.519496953 | 1.238 | 0.360 | 0.537 |
AUC, area under the curve; ppm, parts/million; VIP, variable importance in projection.
*
Resonances for this metabolite were in an overlapped region of the spectrum.