Fig. 1.

Plasma and urine electrolytes and hematocrit in control (wnk4^+/+) and knockout (wnk4^−/−) mice. A: plasma [K⁺]. B: plasma [Cl⁻]. C: plasma [${\text{HCO}}_3^{-}$]. D: hematocrit. E: urine calcium excretion. F: effects of diet on urine calcium excretion. Black symbols indicate high-salt/normal-K⁺ diet (HS/NK), and gray symbols indicate high-salt/low-K⁺ diet (HS/LK). A–E: effects compared with Mann-Whitney U-test. *P < 0.05. For F, 2-way analysis of variance was performed.