Fig. 2.

Evaluation of kidney damage during the development of DKD in SS and SS^Trpc6−/− rats. A and B: representative images of kidney injury with and without STZ treatment. C–E: Immunohistochemical analyses of kidney injury. Quantification of glomerular injury (C), interstitial fibrosis (D), and protein casts (E) in the vehicle- and STZ-treated WT and SS^Trpc6−/− rats. For all histological analysis n = 4 for SS^WT and STZ-SS^WT; n = 5 for SS^Trpc6−/− and STZ-SS^Trpc6−/−. DKD, diabetic kidney disease; SS, salt-sensitive; STZ, streptozotocin; WT, wild type.