Fig. 3.

Evaluation of kidney function. A and C: microalbuminuria and urinary creatinine excretion in STZ-SS^WT and STZ-SS^Trpc6−/− rats compared with control animals; urine samples from 3 days before STZ injection and 20 and 76 days after STZ-injection. B: glomerular filtration rate in control- and STZ-treated rats. D: creatinine clearance in control versus STZ-treated SS^WT and SS^Trpc6−/− rats. *P < 0.05 for SS^WT versus STZ-SS^WT, #P < 0.05 for SS^WT versus STZ-SS^Trpc6−/−, †P < 0.05 for SS^Trpc6−/− versus STZ-SS^Trpc6−/−, ‡P < 0.05 for SS^Trpc6−/− versus STZ-SS^WT, ♦P < 0.05 for STZ-SS^Trpc6−/− versus STZ-SS^WT. GFR, glomerular filtration rate; SS, salt-sensitive; STZ, streptozotocin; TBW, total body weight; WT, wild type.