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. 2018 Aug 6;99(9):1187–1198. doi: 10.1099/jgv.0.001128

Fig. 5.

Fig. 5.

PR8_HA(D-MVEKT) but not PR8_HA(MVEKT) virus replicates to high titres in Tmprss2−/− mice. Female 8–12-week-old WT and Tmprss2−/− mice were infected intranasally with 2×105 f.f.u. PR8 (d2: WT n=8, KO n=7; d4: WT n=5, KO n=5), PR8_HA(HK) (d2: WT n=7, KO n=8; d4: WT n=8, KO n=7), PR8_HA(MVEKT) (d2: WT n=8, KO n=7; d4: WT n=6, KO n=6) and PR8_HA(D-MVEKT) (d2: WT n=7, KO: n=7; d4 WT n=6, KO n=5). On day 2 and 4 p.i., lungs were homogenized and titres were determined by f.f.u. in each lung (each sample was titrated 2–4 times). Mean titres are shown with ± 1 SEM. Statistical significance was determined by a multi-factorial ANOVA and post-hoc t-test with Benjamini-Hochbertg correction for multiple testing. Stars indicate statistical significane results for treatment groups between WT and Tmprss2−/− mice: P-values (**P<0.01, ***P<0.001); ns: non-significant.