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. 2018 Aug 8;120(4):2121–2129. doi: 10.1152/jn.00322.2018

Fig. 2.

Fig. 2.

Dendritic arbors of starburst amacrine cells (SBACs) in the Sox2 conditional knockout (Sox2-CKO) retina are bistratified. A and B: examples of single injected SBACs from wild-type (Sox2-WT) and Sox2-CKO retinas, showing the altered dendritic morphology of SBACs deprived of Sox2. C and D: portions of the dendritic arbor that lie within the 2 cholinergic immunolabeled plexes for these same 2 cells (top and highlighted box in A and B) and for 3 additional cells (bottom) in each condition. In Sox2-WT cells all of the dendritic arbor is contained within the ON stratum (shown in red, C), whereas Sox2-CKO cells show a reduced density of its dendritic arbor in the ON stratum (shown in red, D) and ectopic dendrites present in the OFF stratum (shown in green, D). The entire cholinergic plexus was immunolabeled as well (shown in blue), confirming that the bistratified dendritic arbors localize to the ON and OFF cholinergic strata. Calibration bar, 20 µm.