Table 3.
Measures of M1 and CST function and structure
| Stroke, All (Ipsi-) | Stroke, All (Contra-) | Healthy | t-Test Ispi-/Contra- | t-Test Ipsi-/Healthy | F-Test Ipsi-/Healthy | Stroke, Cort (Ipsi-) | Stroke, Subcort (ipsi-) | t-Test Cort/Subcort | |
|---|---|---|---|---|---|---|---|---|---|
| M1 function | |||||||||
| rMT, %MSO | 67.44 ± 19.88 (18) | 53.17 ± 8.310 (12) | P = 0.01; t(28) = 2.34* | P < 0.01; F(17,11) = 5.72* | 60.50 ± 18.61 | 73.00 ± 20.01 | P = 0.19; t(16) = 1.36 | ||
| AUC, mV | 1.63 ± 2.075 (18) | 3.65 ± 3.11 (12) | P = 0.02; t(28) = 2.14* | P = 0.13; F(11,17) = 0.13 | 60.50 ± 18.61 | 73.00 ± 20.01 | P = 0.15; t(15) = 1.34 | ||
| MEPmax, mV | 0.40 ± 0.399 (15) | 0.87 ± 0.70 (11) | P = 0.02; t(24) = 2.21* | P = 0.06; F(10,14) = 3.05 | 0.327 ± 0.349 | 0.47 ± 0.47 | P = 0.25; t(13) = 0.70 | ||
| M parameter | 0.26 ± 0.13 (13) | 0.28 ± 0.13 (10) | P = 0.36; t(21) = 0.36 | P = 0.93; F(9,12) = 1.03 | 0.303 ± 0.158 | 0.23 ± 0.09 | P = 0.15; t(11) = 1.08 | ||
| S50, %MSO | 65.07 ± 12.29 (15) | 58.66 ± 9.62 (11) | P = 0.07; t(24) = 1.50 | P = 0.44; F(14,10) = 1.63 | 61.16 ± 12.73 | 68.49 ± 11.60 | P = 0.13; t(13) = 1.17 | ||
| SICI, CS60, %MEP | 82.79 ± 31.40 (10) | 62.23 ± 30.70 (12) | P = 0.08; t(20) = 1.47 | P = 0.54; F(11,9) = 0.96 | 81.21 ± 38.93 | 85.15 ± 20.50 | P = 0.43; t(8) = 0.18 | ||
| SICI CS80, %MEP | 78.51 ± 22.30 (10) | 59.73 ± 27.17 (12) | P = 0.05; t(20) = 1.71 | P = 0.29; F(11,9) = 2.05 | 75.89 ± 28.51 | 81.43 ± 10.60 | P = 0.36; t(8) = 0.37 | ||
| Ml structure | |||||||||
| Lesion volume, % | 1.11 ± 1.45 (17) | N/A | N/A | 2.39 ± 1.49 | 0.21 ± 0.33 | P < 0.01; t(15) = 4.51* | |||
| Ml thickness, mm | 2.31 ± 0.23 (17) | 2.43 ± 0.19 (17) | P < 0.04;t(16) = 1.84* | 2.13 ± 0.22 | 2.44 ± 0.12 | P < 0.01; t(15) = 3.64* | |||
| FA of CST | 0.46 ± 0.06 (15) | 0.48 ± 0.04 (15) | P < 0.01;t(14) = 3.09* | 0.47 ± 0.06 | 0.44 ± 0.05 | — |
Measures are reported as means ± SD (n). Stimulus response curve (SRC) parameters were maximum motor-evoked potential [MEPmax (plateau)], M parameter (proportional for the maximum slope), and S50 (transcranial magnetic stimulation intensity that evokes an MEP amplitude of half MEPmax). Ipsi, ipsilesional; Contra, contralesional; rMT, resting motor threshold; AUC, area under the SRC; SICI, short-interval intracortical inhibition; M1, primary motor cortex; FA, fractional anisotropy, CST, corticospinal tract; CS60 and CS80, conditioning stimulus intensity of either 60 or 80% rMT; MSO, maximum stimulator output;
*
indicates significant results.