Table 4.
Multiple linear regression analysis testing the association between the measures of M1 and CST structure and function with the measures of affected hand function
| Covariate |
|||||
|---|---|---|---|---|---|
| Dependent/Independent Variable | n | None | Age | PSD | Lesion Volume |
| Peak wrist acc. | |||||
| rMT | 18 | −0.002 [−0.012, 0.008] (0.754) | −0.001 [−0.013, 0.010] (0.812) | −0.001 [−0.012, 0.009] (0.799) | 0.002 [−0.010, 0.014] (0.730) |
| AUC | 18 | 0.030 [−0.064, 0.124] (0.544) | 0.028 [−0.084, 0.141] (0.596) | 0.024 [−0.078, 0.127] (0.619) | 0.033 [−0.102, 0.167] (0.610) |
| MEPmax | 15 | 0.048 [−0.529, 0.624] (0.874) | 0.047 [−0.638, 0.732] (0.884) | 0.036 [−0.606, 0.677] (0.905) | −0.052 [−0.732, 0.627] (0.868) |
| M parameter | 13 | 0.745 [−1.215, 2.705] (0.472) | 0.926 [−1.447, 3.299] (0.405) | 0.396 [−1.958, 2.749] (0.716) | 0.622 [−1.523, 2.767] (0.528) |
| S50 | 15 | −0.012 [−0.029, 0.006] (0.213) | −0.013 [−0.034, 0.009] (0.217) | −0.011 [−0.031, 0.008] (0.231) | −0.004 [−0.025, 0.017] (0.691) |
| SICI CS60 | 10 | 0.001 [−0.007, 0.010] (0.746) | −0.000 [−0.015, 0.014] (0.943) | 0.001 [−0.010, 0.011] (0.867) | 0.001 [−0.009, 0.011] (0.818) |
| SICI CS80 | 10 | 0.004 [−0.007, 0.015] (0.449) | 0.005 [−0.018, 0.027] (0.618) | 0.004 [−0.010, 0.018] (0.536) | 0.004 [−0.011, 0.019] (0.565) |
| M1 hand | 17 | 0.004 [−0.638, 0.647] (0.989) | 0.017 [−0.744, 0.778] (0.962) | 0.109 [−0.640, 0.859] (0.759) | 0.157 [−0.611, 0.924] (0.668) |
| FA | 15 | 1.138 [−2.284, 4.560] (0.526) | 1.435 [−2.570, 5.439] (0.450) | 3.412 [−1.234, 8.058] (0.136) | 0.588 [−3.308, 4.484] (0.748) |
| Jebsen-Taylor Test | |||||
| rMT | 18 | 0.001 [−0.004, 0.007] (0.654) | 0.002 [−0.005, 0.009] (0.582) | 0.001 [−0.005, 0.008] (0.684) | 0.004 [−0.004, 0.012] (0.299) |
| AUC | 18 | −0.016 [−0.072, 0.039] (0.575) | −0.022 [−0.087, 0.044] (0.491) | −0.015 [−0.077, 0.048] (0.623) | −0.073 [−0.150, 0.004] (0.060) |
| MEPmax | 15 | −0.216 [−0.533, 0.102] (0.206) | −0.245 [−0.613, 0.123] (0.173) | −0.212 [−0.575, 0.151] (0.227) | −0.459 [−0.829, −0.090] (0.019)* |
| M parameter | 13 | 0.345 [−0.671, 1.360] (0.520) | 0.071 [−0.947, 1.090] (0.879) | 0.584 [−0.587, 1.755] (0.293) | 0.118 [−1.169, 1.404] (0.841) |
| S50 | 15 | 0.003 [−0.008, 0.014] (0.589) | 0.004 [−0.009, 0.017] (0.506) | 0.003 [−0.010, 0.015] (0.617) | 0.004 [−0.010, 0.019] (0.528) |
| SICI CS60 | 10 | 0.000 [−0.004, 0.004] (0.984) | −0.002 [−0.008, 0.004] (0.523) | 0.000 [−0.005, 0.005] (0.958) | −0.001 [−0.004, 0.003] (0.661) |
| SICI CS80 | 10 | −0.000 [−0.005, 0.005] (0.954) | −0.004 [−0.014, 0.005] (0.351) | −0.000 [−0.007, 0.007] (0.976) | −0.002 [−0.007, 0.002] (0.239) |
| M1 hand | 17 | −0.260 [−0.647, 0.128] (0.209) | −0.253 [−0.713, 0.206] (0.257) | −0.320 [−0.774, 0.133] (0.152) | −0.240 [−0.720, 0.240] (0.302) |
| FA | 15 | −0.267 [−2.596, 2.062] (0.826) | −0.220 [−2.993, 2.553] (0.866) | −1.626 [−4.870, 1.619] (0.296) | −0.461 [−3.218, 2.297] (0.722) |
The regression coefficient, the confidence interval, and the P values are given {coefficient [CI]; (P)}. Each P value corresponds to the significance of a simple linear regression analysis (no covariate) or multiple linear regression analysis (single covariate) testing the association between the dependent and independent variable. The sample size (n) used for the linear regression analyses of each dependent and independent variable pair is reported. SRC parameters were maximum motor-evoked potential [MEPmax (plateau)], M parameter (proportional for the maximum slope), and S50 (transcranial magnetic stimulation intensity that evokes an MEP amplitude of half MEPmax). rMT, resting motor threshold; AUC, area under the SRC; SICI, short-interval intracortical inhibition; M1 hand, hand area of primary motor cortex; FA, fractional anisotropy of the ipsilesional corticospinal tract; PSD, poststroke duration. CS60 and CS80, conditioning stimulus intensity of either 60 or 80% rMT.
P < 0.05, significant results.