Figure 3.
Radiological findings before and after E+B treatment. (A,B) Brain MRI of case 1 prior to E+B treatment (A) and 18 months after E+B treatment (B). A complete response was observed, with the disappearance of a 10-mm BM (white arrows). (C,D) Brain CT of case 6 prior to E+B treatment (C) and 11 months after E+B treatment (D). More than 10 BMs with edemas of various sizes virtually disappeared (white arrows). (E,F) Brain MRI of case 7 prior to E+B treatment (E) and 15 months after E+B treatment (F). The main BM with edema was good PR and the BM-related symptom of headache improved. E+B, erlotinib plus bevacizumab; BM, brain metastasis; MRI, magnetic resonance imaging; PR, partial response.