Fig. 1.

Spatial learning in Pgf^−/− mice. Compared with Pgf^+/+ mice, Pgf^−/− mice exhibited a significantly lower percent alternation (A) despite no difference in the total number of arm entries (B) in the Y-maze spontaneous alternation test (YMSAT). When stratified by sex, there was no significant difference in percent alternation (C), although female Pgf^+/+ mice made significantly more entries than Pgf^+/+males (D). Each mouse completed the 10 min YMSAT once. Data were analyzed with unpaired, two-tailed t-tests. Graphs show means ± SD. Black circles represent Pgf^+/+ mice, while gray squares represent Pgf^−/− mice; n = 23 Pgf^+/+ and 20 Pgf^−/− male and female mice. *P < 0.05.