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. 2018 Aug 17;50(10):862–875. doi: 10.1152/physiolgenomics.00076.2018

Fig. 5.

Fig. 5.

Pgf−/− mouse performance on the SDT by sex. In the first trial of the SDT, there was no difference in time spent moving (A) between Pgf+/+ and Pgf−/− males and females, although Pgf+/+ females reared significantly more times than Pgf−/− females (B). There was also no difference in percent of time spent in the center between groups (C). Time spent exploring (D) and number of visits made (E) to the objects decreased over the trials but with no significant difference between groups. Likewise, total number of visits made to the objects over the entire SDT was not different between groups (F). Pgf+/+ males, Pgf+/+ females and Pgf−/− males spent significantly more time exploring the changed object than the unchanged objects in the New Location trial (G). However, none of the groups spent significantly more time exploring the changed object(s) relative to the unchanged objects in the Substitution (H), Spatial Switch (I), or Addition (J) trials. No clear sex difference in object recognition memory was apparent. Data were analyzed by two-way ANOVAs and linear mixed models as appropriate. Graphs show means ± SD. Circles represent Pgf+/+ mice, while squares represent Pgf−/− mice. Black bars show the change in time spent investigating the changed object(s), while light gray bars show the change in time investigating the unchanged objects; n = 23 Pgf+/+ and 20 Pgf−/− male and female mice. *P < 0.05, **P < 0.01, ***P < 0.001.