Table 7.

Differentially expressed mRNAs in NFAT cardiac hypertrophy pathway from left ventricle of NHE1 transgenic mouse hearts

Gene Symbol	Entrez Gene ID	Fold Change	Expected Change	Location	Type(s)
ADCY5	224129	2.388	up	plasma membrane	enzyme
AKAP5	238276	2.822	down	plasma membrane	other
AKT3	23797	1.592	up	cytoplasm	kinase
CAMK1	52163	1.816	up	cytoplasm	kinase
CAMK2D	108058	1.711	up	cytoplasm	kinase
GNAI2	14678	2.210	down	plasma membrane	other
GNAS	14683	1.546	up	plasma membrane	enzyme
GNB1	14688	1.944	up	plasma membrane	enzyme
GNB5	14697	1.769	plasma membrane	enzyme
GNB2L1	14694	1.527		cytoplasm	enzyme
GNG11	66066	1.641	up	plasma membrane	enzyme
IGF1	16000	2.952	up	extracellular space	growth factor
IL11	16156	−1.678	up	extracellular space	cytokine
IL6ST	16195	1.752	up	plasma membrane	transmembrane receptor
KRAS	16653	1.558	up	cytoplasm	enzyme
MAP2K1	26395	2.255	up	cytoplasm	kinase
MAP2K2	26396	1.616	up	cytoplasm	kinase
MAP2K6	26399	−1.948	up	cytoplasm	kinase
PDIA3	14827	1.924	up	cytoplasm	peptidase
PIK3C3	225326	1.668	up	cytoplasm	kinase
PLCB4	18798	2.080	up	cytoplasm	enzyme
PRKAR1A	19084	2.492	up	cytoplasm	kinase
PRKAR2A	19087	1.621	up	cytoplasm	kinase
PRKCD	18753	1.999	up	cytoplasm	kinase
RCAN1	54720	5.226	down	nucleus	transcription regulator
RRAS2	66922	2.233	up	plasma membrane	enzyme
SHC1	20416	1.505	up	cytoplasm	kinase
TGFB2	21808	7.666	up	extracellular space	growth factor
TGFB3	21809	3.013	up	extracellular space	growth factor
TGFBR1	21812	1.746	up	plasma membrane	kinase
TGFBR2	21813	1.787	up	plasma membrane	kinase

Ratio, 31/179 (0.173); z-score, 3.528; P value, 3.26E-05. NFAT, nuclear factor of activated T cells.