Fig. 2.
Voltage-gated Ca2+ channel (VGCC) blocker inhibits Ca2+ waves. Data are means ± SE (n = 4) before [physiological salt solution (PSS)] and in the presence of the VGCC blocker nifedipine (1 μM) for global Fluo-4 intensity relative to the mean value in PSS (a measure of global myoplasmic Ca2+ concentration; A), internal diameter (B), and the occurrence (number of waves/cell), amplitude (F/Fo), and frequency (Hz) of Ca2+ waves as indicated (C). *P < 0.05 compared with PSS via paired t-tests. F, fluorescence intensity; Fo, baseline fluorescence.