Table 1.
Ca2+/calmodulin-dependent protein kinase II-dependent phosphorylation of Nav1.5 does not alter conduction velocity during ischemia-reperfusion
| WT |
S571E |
S571A |
WT + Mexiletine |
|||||
|---|---|---|---|---|---|---|---|---|
| Longitudinal | Transverse | Longitudinal | Transverse | Longitudinal | Transverse | Longitudinal | Transverse | |
| Baseline | 57.6 ± 1.7 | 35.6 ± 1.5 | 53.8 ± 3.0 | 27.4 ± 2.8 | 57.6 ± 1.7 | 38.2 ± 1.6 | 56.2 ± 1.8 | 36.2 ± 0.14 |
| Ischemia-reperfusion (5 min) | 56.8 ± 2.0 | 36.4 ± 2.1 | 53.2 ± 3.6 | 26.2 ± 3.0 | 57.6 ± 1.4 | 38.0 ± 0.7 | 54.0 ± 1.1 | 35.0 ± 1.3 |
Values (in cm/s) are means ± SE; n = 5 independent preparations for all groups. WT, wild-type. P = not significant.