Fig. 12.

Male db/db mice had microvascular rarefaction. A and B: microvascular density was assessed in db/db and lean wild-type (WT) mouse hearts using Griffonia simplicifolia (GSL)-I lectin staining. C: db/db mice had a trend toward reduced microvascular density at 6 and 12 mo of age. D and E: although female db/db mice had comparable microvascular density with age-matched WT control mice, male mice exhibited a markedly lower microvascular density (n = 4 male mice/group, n = 4 female mice/group, n = 8 male + female mice/group). Scale bar = 50 μm. **P < 0.01 and ***P < 0.001.