. 2018 Jul 6;315(4):H814–H825. doi: 10.1152/ajpheart.00076.2018

Table 1.

MMP-sensitive gel release of recombinant TIMP-3: effects on LV function and geometry

	EF, %	LVEDV, ml	LVESV, ml	LVPWThd, cm	LV Mass, g	LA Area, cm²	E/A	PCWP, mmHg
Baseline (n = 21)
Day 0	60.1 ± 0.7	37.3 ± 0.9	11.8 ± 0.7	0.79 ± 0.01	66.3 ± 1.14	6.60 ± 0.16	1.15 ± 0.02	4.01 ± 0.07
MI/saline (n = 7)
Day 3	45.8 ± 1.9^*	68.9 ± 4.0^*	38.8 ± 4.0^*	0.64 ± 0.01^*	80.2 ± 3.06^*	8.10 ± 0.45^*	1.33 ± 0.05^*	6.34 ± 0.71^*
Day 7	42.9 ± 1.8^*	77.4 ± 4.8^*	45.4 ± 5.6^*	0.56 ± 0.03^*	79.9 ± 4.0^*	9.25 ± 0.36^*	1.45 ± 0.04^*	8.45 ± 1.17^*
Day 14	39.2 ± 1.7^*	84.4 ± 5.5^*	50.2 ± 5.7^*	0.52 ± 0.02^*	85.3 ± 3.9^*	10.09 ± 0.43^*	1.56 ± 0.05^*	10.89 ± 1.09^*
Day 21	37.4 ± 1.9^*	98.4 ± 9.4^*	57.2 ± 7.9^*	0.49 ± 0.03^*	90.3 ± 5.4^*	10.95 ± 0.43^*	1.70 ± 0.07^*	10.93 ± 0.90^*
Day 28	34.4 ± 2.0^*	109.1 ± 10.5^*	66.4 ± 9.9^*	0.47 ± 0.03^*	94.3 ± 6.1^*	11.88 ± 0.29^*	1.80 ± 0.04^*	12.75 ± 1.00^*
MI/HAMMPS (n = 7)
Day 3	47.9 ± 1.5^*	62.4 ± 5.8^*	32.2 ± 4.0^*	0.69 ± 0.01^*†	82.2 ± 5.4^*	9.46 ± 0.40^*†	1.38 ± 0.05^*	5.94 ± 0.72^*
Day 7	45.1 ± 1.8^*	69.9 ± 6.0^*	36.4 ± 4.1^*	0.60 ± 0.02^*	78.9 ± 4.5^*	9.74 ± 0.44^*	1.42 ± 0.05^*	6.68 ± 0.68^*
Day 14	41.1 ± 2.0^*	78.4 ± 9.8^*	43.5 ± 7.7^*	0.57 ± 0.03^*	86.6 ± 7.3^*	10.83 ± 0.38^*	1.52 ± 0.05^*	8.26 ± 0.78^*
Day 21	39.2 ± 2.1^*	91.0 ± 12.4^*	52.1 ± 10.8^*	0.53 ± 0.02^*	92.8 ± 8.7^*	11.55 ± 0.53^*	1.64 ± 0.07^*	9.56 ± 0.72^*
Day 28	37.1 ± 2.0^*	102.4 ± 13.5^*	59.0 ± 9.8^*	0.49 ± 0.02^*	96.8 ± 8.7^*	12.59 ± 0.55^*	1.71 ± 0.07^*	10.44 ± 0.58^*
MI/HAMMPS/rTIMP-3 (n = 7)
Day 3	54.6 ± 0.9^*†‡	50.0 ± 1.8^*†	20.5 ± 1.6^*†‡	0.73 ± 0.02^*†	77.2 ± 2.0^*	7.87 ± 0.20^*‡	1.26 ± 0.02^*	4.19 ± 0.11†‡
Day 7	51.5 ± 1.6^*†‡	55.4 ± 1.7^*†‡	25.8 ± 2.5^*†	0.67 ± 0.02^*†	75.6 ± 2.4^*	8.56 ± 0.27^*‡	1.30 ± 0.02^*†‡	5.42 ± 0.49^*†
Day 14	49.4 ± 1.8^*†‡	60.1 ± 2.5^*†	31.7 ± 2.2^*†	0.63 ± 0.03^*†	74.1 ± 2.6^*†	9.28 ± 0.19^*‡	1.37 ± 0.02^*†‡	6.43 ± 0.36^*†
Day 21	47.7 ± 1.5^*†‡	66.8 ± 2.8^*†	34.2 ± 2.5^*	0.61 ± 0.03^*†‡	82.4 ± 3.0^*	9.86 ± 0.20^*†‡	1.46 ± 0.02^*†‡	7.13 ± 0.43^*†‡
Day 28	45.5 ± 1.3^*†‡	72.2 ± 2.5^*†‡	38.1 ± 1.8^*†	0.60 ± 0.02^*†‡	85.7 ± 2.4^*	10.27 ± 0.24^*†‡	1.57 ± 0.03^*†	7.21 ± 0.42^*†‡

Values are means ± SE; n, number of samples. EF, LV ejection fraction; LVEDV, left ventricular (LV) end-diastolic volume; LVESV, LV end-systolic volume; LVPWThd, diastolic LV posterior wall thickness; LA area, left atrial area; E/A, early-to-late transmitral filling velocity rates; PCWP, pulmonary capillary wedge pressure; MI, myocardial infarction; HAMMPS, matrix metalloproteinase (MMP)-sensitive hyaluronic acid (HA) gel; rTIMP-3, recombinant tissue inhibitor of metalloproteinase-3.

P < 0.05 vs. baseline;

^†

P < 0.05 vs. the respective MI group only;

^‡

P < 0.05 vs. the respective MI/HAMMPS group.