Table 3.
MicroRNAs in our ovine model of congenital heart disease. with adaptive RV hypertrophy and other animal models of RV hypertrophy and RV failure as well as human RV failure
| RV Failure |
||||
|---|---|---|---|---|
| MicroRNA | Shunt RV | Pulmonary artery banding | Hypoxia and Sugen | Monocrotaline |
| miR-29a | Increased | Decreased | Unchanged | |
| miR-30a-5p | Increased | Decreased | Decreased | |
| miR-92a | Increased | Decreased | ||
| miR-126 | Unchanged | |||
| miR-127-3p | Increased | Increased | Decreased | |
| miR-155 | Unchanged | Increased | ||
| miR-199b-5p | Decreased | Increased | ||
| miR-200b | Increased | Decreased | ||
| miR-208a-3p | Decreased | Decreased | Decreased | |
| miR-379-5p | Increased | Increased | Decreased | |
| miR-338-3p | Increased | Decreased | ||
Selected microRNAs (miRNAs) were compared with other notable published models of right ventricular (RV) hypertrophy and RV failure. Antifibrotic miR-29a was increased in our model but decreased in RV failure secondary to pulmonary artery banding. Additionally, miR-199b-5p, which was increased in our model, was also decreased in pulmonary artery banding RV failure as well as human RV failure. Pulmonary artery banding RV failure data are from Ref. 26, hypoxia and Sugen RVF data from Ref. 10, and monocrotaline RVF data from Refs. 25 and 32.