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. 2018 Nov 3;20:442–450. doi: 10.1016/j.redox.2018.11.001

Fig. 2.

Fig. 2

Red blood cell bioactivation of nitrite is enhanced by far red light. (A) Platelet activation in the absence of RBCs. Platelets in platelet rich plasma (PRP) were activated with 1 μM ADP compared to baseline. Exposure to far red light (FR, 660 nm, 560 mW, 5 min) had no effect on baseline activation or PRP with ADP. n = 9. (B) Platelet activation in the presence of deoxygenated RBCs. Nitrite (10 μM) reduced platelet activation in the presence of deoxygenated RBCs (15% Hct, *P < 0.02, paired t-test, n = 9). Illumination with far red light also reduced platelet activation compared to control (*P < 0.02, paired t-test, n = 9). Data are plotted as mean ± one standard error. The combination of light and nitrite treatments further reduced platelet activation (#P < 0.001, paired t-test FR + nitrite vs FR, n = 9). Data are plotted as mean ± one standard error.