FIGURE 1.

Lack of IP₃R2-dependent astrocytic calcium prevents age-related cognitive decline in a PFC-dependent task. (A) Representative heatmaps of cumulative time exploration of start (S), familiar (F), and novel (N) arms of the Y-maze for WT (left, black) and IP₃R2 KO (right, red) mice (warm colors, more time; cold colors, less time); Discrimination index (D.I.) for time (B) and distance (C), representative of the spatial preference for the novel arm in the retrieval trial. (D) Total distance traveled in the maze; (E) Total number of entries in the three arms. Adult mice are represented in filled bars; aged mice are represented in unfilled bars. n = 9–13 per group, two-way ANOVA, Sidak’s multiple comparisons test; data plotted as mean ± SEM. ^∗p < 0.05.