Table 1.
γδ17 induction and function in inflammatory disease
| Disease | Disease model | Dominant subset | Induction of γδ17 cells | γδ17 function | References |
|---|---|---|---|---|---|
| Rheumatoid arthritis (RA) | collagen‐induced arthritis | Vγ4+ Vδ4+ | Mycobacterium tuberculosis components in complete Freund's adjuvant (CFA) or subsequent cytokine induction | Promote Th17 cells | 22, 24, 60 |
| Il1rn −/− mice | Vγ6+ Vδ1+ | Up‐regulation of interleuki ‐1 receptor (IL‐1R) | IL‐17‐induced hyperinflammation | 20 | |
| Spondyloarthritides (SpA) | IL‐23 overexpression | Vγ6+ | Hyper IL‐23 induction | IL‐17‐induced hyperinflammation | 65 |
| Multiple sclerosis (MS) | EAE | Vγ4+ | IL‐1β and IL‐23 from dendritic cells (DC) induced by Mycobacterium tuberculosis components in CFA | Promote Th17 cells, and suppress regulatory T cells | 21, 61 |
| Uveitis | EAU | Vγ4+ Vδ4+ | Components in CFA or subsequent cytokine induction | Promote Th17 cells | 104 |
| Psoriasis | IMQ | Vγ4+ and Vγ6+ | Imiquimod (IMQ)‐induced IL‐23 from DC | IL‐17 production and subsequent neutrophil inflammation | 9, 10, 23, 35, 42, 64 |
| IL‐23 | Hyper IL‐23 induction | IL‐17 production and subsequent neutrophil inflammation | 23 | ||
| Uveoretinitis in autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy (APCED) | Aire −/− mice | Vγ6+ Vδ1+ | Up‐regulation of IL‐7 in the thymus | IL‐17‐induced hyperinflammation | 44 |
| Skin graft rejection | Male to female skin transplantation | Vγ4+ | Accumulation CCR6+ γδ17 cells in skin graft | IL‐17 promotes the accumulation of DC in draining lymph nodes to subsequently activate Th17 cells | 66 |