Subject area	Neuroscience, Proteomics
More specific subject area	Neurobiology, Aging, Protein homeostasis, Redox biology
Type of data	Spreadsheets
How data was acquired	Liquid chromatography / mass spectroscopy. Thermo Scientific LTQ Orbitrap XL or Thermo Scientific™ Q Exactive Plus equipped with an ultra-high performance liquid chromatography unit and a Nanospray Flex Ion-Source, Xcalibur acquisition, MaxQuant search
Data format	Excel Table 1: MaxQuant data of normalized SILAC proteome (vehicle versus 6 h rapamycin)
	Excel Table 2: Gene Ontology analysis of significantly regulated proteins (SILAC experiment)
	Excel Table 3: MaxQuant data of label-free deep proteome (conditions: full medium, 24 h serum-free, 24 h rapamycin)
Experimental factors	Cell treatment and harvest, protein extraction, storage at −80 °C, chromatography and MS analysis, MaxQuant software and Perseus software, gene ontology annotation
Experimental features	nNOS+ (neuronal nitric oxide synthase) and MOCK transduced SH-SY5Y neuroblastoma cells without and with rapamycin treatment for 6 h and 24 h or serum-free starvation for 24 h versus control conditions
Data source location	Frankfurt, Germany
Data accessibility	Data is with this article.
	Raw mass spectra and raw MaxQuant output tables, and a description of the sample processing are deposited to the ProteomeXchange Consortium[2]via the PRIDE partner repository with the dataset identifier PRIDE: PXD010538, which is publicly available.