Table 4.

Kinetic parameters of reported manganese catalase mimetics containing tripodal amine ligands and the natural enzyme.

Compound	kcat (s−1)	KM (mM)	kcat/Km (M−1 s−1)	Solvent system	References
1a	2.59 ± 0.12	11.7 ± 1.1	221.3	H2O + piperazine	This work
1b	0.58 ± 0.03	7.23 ± 0.48	80.2	H2O + piperazine	This work
[Mn${}_2^{\text{II}}$(tpa)2(μ-Cl)2]2+	107	3.1	34,516	CH3CN	Shin et al., 2010
[Mn${}_2^{\text{II}}$(tpa)2(μ-Cl)2]2+	1.97	1.47	1,340	CH3CN + H2O	Shin et al., 2010
[MnII(bpia)(μ-OAc)]${}_2^{2+}$	1,100	31.5	34,000	CONHCH3	Triller et al., 2002
[Mn2(L1-L5)2Cl2]	87.8–283	18–54.3	2,750–7,800	H2O/MeOH	Reddig et al., 2004
CAT(T. thermophilus)	2.6 × 105	83	3.1 × 106		Shank et al., 1994

^aEvaluated by UV-Vis spectroscopy by following H₂O₂ consuption.

^bMeasured by electrochemical O₂ detection.

Tpa, (tris(2-pycolyl)amine); bpia, bis-(picolyl)(N-methylimidazol-2-yl)amine); L1-L₅, derivatives of 2-{[bis(pyridin-2-ylmethyl)amino]methyl}phenol.