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Fibril growth and EM analysis of P301S- and P301L-seeded reactions. 5% of seeds of P301S and P301L fibrils were mixed with 10 μm Tau monomers. A and B, growth of Tau monomers onto P301S seeds (A) and P301L seeds (B) was monitored by ThT fluorescence at 37 °C (n = 4). Error bars represent means ± S.D. C and D, afterward, all reactions were analyzed by EM. Scale bars, 200 nm. The data reveal that htau23 monomers are unable to grow onto P301S and P301L seeds.
