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. 2018 Oct 4;293(45):17308–17316. doi: 10.1074/jbc.R118.003213

Figure 1.

Figure 1.

Lipid synthetic pathways in the asexual stages of Plasmodium. The following abbreviations are used: RBCM, red blood cell membrane; RBCC, red blood cell cytosol; PPM, parasite plasma membrane; DV, digestive vacuole; HZ, hemozoin; P/AA, peptides and amino acids; PfPSS, P. falciparum PS synthase; PfSD, P. falciparum serine decarboxylase (asterisk indicates that enzyme activity has been reported but no corresponding gene has been identified); PfPLC, P. falciparum phospholipase C; PfPSD, P. falciparum PS decarboxylase; PfCT, P. falciparum choline transporter; PfCK, P. falciparum choline kinase; PfCCT, P. falciparum CTP:phosphocholine cytidylyltransferase; PfCEPT, P. falciparum choline/ethanolamine-phosphotransferase; PfPMT, P. falciparum phosphoethanolamine methyltransferase; LD-PLC, lyso-PC–dependent phospholipase C; PfNSM, P. falciparum neutral sphingomyelinase; LD-PLD, lyso-PC–dependent phospholipase D. Dashed arrows represent putative routes of transport and metabolism. The “?” indicates pathways and enzymes that might exist or catalyze certain reactions respectively but that have not been identified yet.