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. 2018 Sep 18;293(45):17546–17558. doi: 10.1074/jbc.RA118.005484

Figure 3.

Figure 3.

Progressive retina degeneration in Rab28−/− mice. A, immunostaining of retina frozen sections with anti-GC1 antibody (top panels) and with anti-cone arrestin (bottom panels) at 1, 3, 6, and 13 months of age. Note the gradual reduction of ROS length and ONL thickness and the more rapid cone degeneration. Scale bar, 20 μm. B and C, decline of scotopic a-wave (B) and photopic b-wave amplitudes (C) at 1, 3, 6, and 13 months of age. D–F, average ONL thickness (D), ROS length (E), and cone density (F) of WT and Rab28−/− retina near optic nerve at 1, 3, 6, and 13 months of age. All are significantly reduced at 3, 6, and 13 months. Shown are mean ± S.D. (error bars), n = 4, one-way ANOVA. *, p < 0.05; **, p < 0.01; ***, p < 0.001.