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| properties | 17 | 23 | NMS-873 |
|---|---|---|---|
| p97 IC50 (nM) | 50 | 20 | 11 |
| solubility (μM) | 380 | 330 | 86 |
| HLM (t1/2, min) | 569 | 475 | <10 |
| MLM (t1/2, min) | 386 | 277 | <10 |
| UbG76 V-GFP EC50 (μM) | |||
| 1 h | 19 | 15 | 1.4 |
| 6 h | >40 | >40 | 2.1 |
| NCI-60 mean log GI50 | –5.8 | –5.7 | –6.1 |
