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| species | dosea (iv/po) | Fub (%) | Clc | Vd (K/kg) | t1/2 (h) | F (%) |
|---|---|---|---|---|---|---|
| rat | 1/2 | 5.7 | 15.2 | 2.38 | 1.9 | 41 |
| dog | 0.25/1 | 4.4 | 2.2 | 2.82 | 16.5 | 72 |
| rhesus | 0.25/1 | 5.4 | 11.8 | 1.39 | 2.0 | 40 |
Dosed in mg/kg.
Measured at 0.1 μM concentration with [3H-10]; Fu (%) for human and mouse are 2.2 and 4.6, respectively.
Measured in mL/kg/min.
