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| plasma exposure (nM @ 3 h) | |||
|---|---|---|---|
| oral dose (mg/kg) | blood glu AUC (change %)a | whole blood | unbound |
| 3 | –84** | 351 | 16.1 |
| 1 | –74* | 131 | 6.0 |
| 0.3 | –59* | 34 | 1.6 |
| 0.1 (MED)b | –58* | 11 | 0.5 |
| 0.03 | –23 | 4 | 0.2 |
Reduction in blood glucose AUC as compared to vehicle, n = 8.
MED = minimal dose for significant efficacy. *P < 0.01 vs veh; **P < 0.001 vs veh.
