Table 3.
Summary of GSK2256098 pharmacokinetic parameter values
| Dose (mg) | Cmax (ng/mL), Geometric Mean (%CVb) | Cavg (ng/mL) | tmax (h), Median (range) | AUC(0–4) (ng*h/mL), Geometric Mean (%CVb) | |
|---|---|---|---|---|---|
| Day 1 | 500 (n = 3) | 3075 (108) | 1.5 (1.0, 2.2) | 7038 (78.0) | |
| 750 (n = 4) | 4912 (14.7) | 3.0 (1.5, 4.0) | 8644 (49.0) | ||
| 1000 (n = 6) | 4079 (80.1) | 2.0 (1.5, 4.0) | 9330 (102) | ||
| Day of imaging procedure | 500 (n = 3) | 3262 (113) | 1548 (78.6) | 8608 (93.7) | |
| 750 (n = 2) | 5860 (32.9) | 2338 (40.3) | 10,639 (11.7) | ||
| 1000 (n = 3) | 3803 (82.8) | 1753 (60.3) | 10,286 (67.3) |
%CVb = between-subject coefficient of variation; AUC(0–4) = area under the DBS concentration-time curve to the last quantifiable concentration; Cavg = average concentration over the dose interval; Cmax = maximum observed concentration; DBS = dried blood spot.
Data reported as geometric mean (%CVb).