Skip to main content
. 2018 May 4;20(12):1661–1671. doi: 10.1093/neuonc/noy073

Fig. 1.

Fig. 1

Predictability of WHO tumor grade (HGG vs LGG) in newly diagnosed untreated glioma. (A, B) dns-APT allowed prediction of WHO tumor grade with highest AUC for the dns-APT90 metric (0.83) and a test sensitivity/specificity of 0.63 (0.41–0.81)/1.00 (0.48–1.00) (P < 0.05). Two exemplary patients with HGG (GBM, c1–g1) and LGG (oligodendroglioma II, c2–g2) shown: ci: GdCE T1-w, di: T2-w (TSE), relaxation-compensated multipool CEST MRI at 7T with separated APT (ei), NOE (fi), and dns-APT (gi) effects (unit: %). The GBM patient shows only a small spot-like contrast enhancement in the tumor region (c1), while a clear hyperintensity displays within the tumor at dns-APT imaging (g1, white arrow).