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. 2018 May 4;20(12):1661–1671. doi: 10.1093/neuonc/noy073

Fig. 2.

Fig. 2

Predictability of IDH mutation status (IDH1-R132H wt versus mutation) in newly diagnosed untreated glioma. (A, B) APT and dns-APT CEST metrics allowed prediction of IDH mutation status with highest AUC for the dns-APT90 metric (0.98) with a test sensitivity/specificity of 0.95 (0.77–1.00)/1.00 (0.59–1.00) (P < 0.0001). Two exemplary patients with newly diagnosed GBM IDH-wt (c1 –g1) and IDH-mut (c2 –g2) shown: ci: GdCE T1-w, di: T2-w (TSE), relaxation-compensated multipool CEST MRI at 7T with separated APT (ei), NOE (fi), and dns-APT (gi) effects (unit: %). A ring-like hyperintensity can be delineated in the periphery of the IDH-wt glioblastoma at dns-APT imaging (g1, white arrow), while the IDH-mut GBM displays barely hyperintense at dns-APT (g2, white arrow). The head of the caudate nucleus also displays hyperintense on dns-APT images (g2, pink arrows).