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. 2018 Oct 20;14(13):1883–1891. doi: 10.7150/ijbs.27854

Figure 2.

Figure 2

PKM2 was upregulated in cisplatin resistant BC cells. (A) T24 and SW780 parental and resistant BC cells were treated cisplatin (Cis) as indicated dosages for 24 hours, and subsequently analyzed with MTT assay. Left, the survival curve; right, the IC50 values. (B) Apoptosis of T24 and SW780 parental and resistant BC cells treated with 25 µM cisplatin was determined by Hoechst 33258 staining. (C) The caspase-3/7 activity in T24 and SW780 parental and resistant BC cells treated with 25 µM cisplatin. (D) The expression of PKM2 in T24 and SW780 parental and resistant BC cells. *, p<0.05; **, p<0.01; ***, p<0.001.