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. 2018 Oct 19;14(13):1800–1812. doi: 10.7150/ijbs.26962

Figure 2.

Figure 2

Consequence of SD, SICD and necrosis. In nonrenewable cell types, SD, SICD or necrosis may cause hypertrophy of the remaining cells to restore the cell-death-caused functional loss. In renewable cell types, SD, SICD or necrosis triggers regeneration that usually results in over regeneration and ensuing apoptosis of the over-regenerated cells, which is a one-way procedure because apoptosis will not trigger regeneration.