Table 2.

Univariate and multivariate Cox proportional hazards regression analysis for OS

Variable	Univariate analysis			Multivariate analysis
	HR (95% CI)	P		HR (95% CI)	P
Gender				-	-
Male	Reference
Female	0.85 (0.53-1.36)	0.495
Age(years)				-	-
≤42	Reference
>42	0.32 (0.19-0.53)	<0.001
Family history				-	-
Yes	Reference
No	0.92 (0.58-1.46)	0.735
Smoking behavior				-	-
Yes	Reference
No	1.03 (0.69-1.53)	0.901
TNM stage				1.40 (1.06-1.86)	0.019
I	Reference
II	1.08 (0.40-2.87)	0.885
III	2.75 (1.43-5.30)	0.003
IV	6.61 (3.35-12.72)	<0.001
Histological type				-	-
Adenocarcinoma	Reference
Squamous cell carcinoma	0.89 (0.58-1.38)	0.603
Other	1.68 (0.68-4.17)	0.265
Size(cm)				-	-
≤6.0	Reference
>6.0	2.35 (1.50-3.70)	<0.001
Treatment				1.76 (1.28-2.40)	<0.001
Surgery	Reference
Surgery and Radiotherapy/ Chemotherapy	0.91 (0.47-1.74)	0.772
Radiotherapy/ Chemotherapy	3.80 (2.11-6.84)	<0.001
Other	6.99 (3.47-14.06)	<0.001
ALB(g/L)				-	-
≤37.6	Reference
>37.6	0.40 (0.25-0.66)	<0.001
CRP(mg/L)				1.76 (1.09-2.84)	0.020
≤9.5	Reference
>9.5	2.70 (1.81-4.03)	<0.001
WBC (10^9/L)				-	-
≤10.0	Reference
>10.0	1.92 (1.17-3.14)	0.009
Neutrophil(10^9/L)				-	-
≤7.5	Reference
>7.5	2.66 (1.61-4.40)	<0.001
Lymphocyte(/10^9/L)				-	-
≤1.8	Reference
>1.8	0.80 (0.54-1.19)	0.268
Platelet(10^9/L)				0.43 (0.22-0.83)	0.012
≤163	Reference
>163	0.50 (0.30-0.84)	0.009
NLR				-	-
≤4.30	Reference
>4.30	3.30 (1.96-5.55)	<0.001
PLR				-	-
≤109.5	Reference
>109.5	1.57 (1.04-2.38)	0.034
PNI				-	-
≤48.1	Reference
>48.1	0.40 (0.26-0.63)	<0.001