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DHM alleviates the mitochondrial dynamic imbalance through enhancing SIRT3. (A, B) The effects of DHM on mitochondrial dynamics markers in chondrocytes. Representative western blots of and quantitative data for DRP1, MFN2 and FIS1 levels of chondrocytes in each group. (C, D) Activation of SIRT3 by DHM promoted mitochondrial fission and fusion against TNF-α. All experiments were performed as mean ± SD of 5 times in duplicates. *P < 0.05, **P < 0.01.
