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DHM promotes mitophagy via up-regulating SIRT3 in rat chondrocytes treated with TNF-α. (A, B) The effects of SIRT3 on levels of NIX and BNIP3. Representative western blots of and quantitative data for NIX and BNIP3 levels in each group. (C) DHM induced more co-localization of LC3 and NIX via activating SIRT3 in chondrocytes. Immunofluorescent signals were labeled by LC3 (green) and NIX (red). All experiments were performed as mean ± SD of 5 times in duplicates. *P < 0.05, **P < 0.01.
