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. 2018 Oct 20;14(13):1892–1900. doi: 10.7150/ijbs.28620

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DJ-1 enhances hepatic fatty acid oxidation in HFD-mediated mice model. (A) The relative mRNA expression of genes related to fatty acid synthesis in WT and DJ-1^-/- mice after HFD administration for 24 weeks. (B) Representative Western blots (left) and quantification (right) for the expression of p-SREBP-1C, m-SREBP-1C and ACLY in the liver of WT and DJ-1^-/- mice after HFD administration for 24 weeks. β-actin was used as the loading control. (C) The mRNA expression of glycolysis-related genes was analyzed by RT-PCR. (D) Hepatic lactic acid contents in WT and DJ-1^-/- mice at the end of 24^th week of HFD feeding. (E) The relative mRNA expression of genes related to fatty acid oxidation in WT and DJ-1^-/- mice after HFD administration for 24 weeks. (F) The expression of TCA cycle related gene was analyzed by RT-PCR in WT and DJ-1^-/- mice after HFD administration for 24 weeks. *P < 0.05, **P < 0.01, *** P < 0.001.