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. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: J Thromb Haemost. 2018 May 20;16(6):1164–1175. doi: 10.1111/jth.14127

Figure 5. Mutants showing relatively lower resistance in VKORL1 than in VKORC1 can be converted to show higher resistance under the background of warfarin-sensitive VKORL1.

Figure 5.

The IC50s of resistant mutations are normalized to the different backgrounds, i.e., IC50s of wild-type VKORC1, wild-type VKORL1, and VKORL1 with the sensitive mutations, respectively. The error bars are s.e.m. with error propagation calculated for the normalization.