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. Author manuscript; available in PMC: 2018 Nov 12.
Published in final edited form as: J Am Chem Soc. 2018 Sep 11;140(38):12102–12110. doi: 10.1021/jacs.8b06738

Figure 1.

Figure 1.

Structures of the bicyclic peptide library, hit #4, and peptide 7. Amino acid residues in peptide 7 are numbered from N- to C-terminus. The CPP sequence is shown in red, whereas the residues modified during optimization are shown in blue color. B, β-alanine; CPP, cell-penetrating peptide; Hmb, hydroxylmethylbenzoyl; Pra, propargylglycine; Δ, l-2,3-diaminopropionic acid (Dap).