Fig. 3.

Enrichment of fetal brain transcript eQTL within variants associated with complex post-natal traits. Enrichments were tested at four GWAS P value thresholds (P < 5 × 10^− 5, 5 × 10^− 6, 5 × 10^− 7, and 5 × 10^− 8) for each trait. Top panel shows log10 P values at each threshold. The bottom panel shows the natural log of the odds ratio, with 95% confidence intervals, at each threshold. Only traits for which the significance of eQTL enrichment survives correction for multiple tests (P < 0.001; dotted line in upper panel) at one or more GWAS P value threshold are shown. There are no overlaps between fetal brain eQTL and risk variants for bipolar disorder at the P < 5 × 10^− 8 threshold