Table 2.
Unadjusted (PR) and adjusted (aPR) carriage prevalence ratios for all pneumococci, ten-valent pneumococcal conjugate vaccine (PCV10) serotypes, and non-PCV10 serotypes compared with 2012
|
2013 |
2014 |
2015 |
||||
|---|---|---|---|---|---|---|
| PR (95% CI) | aPR* (95% CI) | PR (95% CI) | aPR* (95% CI) | PR (95% CI) | aPR* (95% CI) | |
| All pneumococci | ||||||
| 5–8 weeks† | 0·78 (0·64–0·96) | 0·89 (0·68–1·15) | 0·52 (0·40–0·66) | 0·69 (0·51–0·95) | 1·17 (0·98–1·40) | 1·29 (1·05–1·58) |
| 12–23 months† | 0·96 (0·84–1·09) | 0·78 (0·68–0·90) | 0·65 (0·55–0·76) | 0·64 (0·54–0·76) | 0·90 (0·79–1·03) | 0·91 (0·79–1·05) |
| 2–6 years† | 0·87 (0·77–0·98) | 0·85 (0·73–0·99) | 0·63 (0·54–0·73) | 0·69 (0·59–0·81) | 0·82 (0·72–0·93) | 0·90 (0·79–1·03) |
| Caregivers | 1·26 (0·90–1·76) | 1·23 (0·81–1·86) | 0·63 (0·42–0·95) | 0·68 (0·43–1·07) | 0·75 (0·51–1·11) | 0·82 (0·54–1·23) |
| PCV10 serotypes | ||||||
| 5–8 weeks | 0·62 (0·40–0·96) | 0·44 (0·26–0·77) | 0·36 (0·21–0·62) | 0·34 (0·18–0·66) | 0·61 (0·39–0·96) | 0·56 (0·34–0·93) |
| 12–23 months | 0·84 (0·66–1·08) | 0·63 (0·48–0·83) | 0·36 (0·25–0·50) | 0·37 (0·26–0·52) | 0·33 (0·23–0·47) | 0·34 (0·23–0·49) |
| 2–6 years | 0·68 (0·52–0·88) | 0·56 (0·40–0·79) | 0·35 (0·25–0·49) | 0·35 (0·24–0·52) | 0·42 (0·30–0·58) | 0·47 (0·34–0·66) |
| Caregivers | 1·41 (0·68–2·92) | 1·24 (0·47–3·30) | 0·65 (0·27–1·59) | 0·76 (0·26–2·17) | 0·33 (0·11–1·02) | 0·43 (0·13–1·42) |
| Non-PCV10 serotypes | ||||||
| 5–8 weeks† | 0·85 (0·65–1·09) | 1·16 (0·85–1·60) | 0·58 (0·43–0·78) | 0·92 (0·63–1·34) | 1·46 (1·17–1·82) | 1·72 (1·33–2·22) |
| 12–23 months | 1·15 (0·96–1·38) | 1·09 (0·90–1·32) | 0·86 (0·70–1·05) | 0·91 (0·74–1·12) | 1·27 (1·06–1·51) | 1·28 (1·07–1·54) |
| 2–6 years† | 0·95 (0·81–1·11) | 0·99 (0·82–1·20) | 0·69 (0·58–0·83) | 0·78 (0·65–0·95) | 0·94 (0·80–1·10) | 1·05 (0·89–1·23) |
| Caregivers | 1·24 (0·83–1·83) | 1·28 (0·80–2·06) | 0·67 (0·42–1·07) | 0·74 (0·45–1·23) | 0·83 (0·53–1·28) | 0·90 (0·57–1·43) |
Variables were adjusted for each age group. 5–8 weeks: ethnicity, two or more children younger than 5 years in the household (multiple under-5s), symptoms of upper respiratory tract infection (URTI), poverty, method of delivery, breastfeeding status, and month of swab collection. 12–23 months: ethnicity, residential location, multiple under-5s, URTI, poverty, and month of swab collection. 2–6 years: ethnicity, residential location, multiple under-5s, exposure to household cigarette smoke, URTI, poverty, and month of swab collection. Caregivers: ethnicity, sex, multiple under-5s, URTI, poverty, and month of swab collection.
Log-binomial regression model data did not converge, so a Poisson regression model was used to estimate adjusted prevalence ratios.